Polythiazide, Structure, Mechanism of Action, Drug Interactions, Therapeutic Uses, Adverse effects and Contraindications
Polythiazide Polythiazide is a medication that belongs to the class of diuretics, specifically thiazide diuretics. Thiazide diuretics are commonly used to treat high blood pressure (hypertension) and edema (fluid retention) associated with various conditions such as heart failure, kidney disorders, and liver cirrhosis. one of the common brand names for polythiazide is "Renese." Mechanism Of Action The mechanism of action of thiazide diuretics, including polythiazide, involves several steps within the kidneys. Here is a simplified explanation of their mechanism: 1. Inhibition of Sodium-Chloride Symporter: Thiazide diuretics inhibit the sodium-chloride symporter in the distal convoluted tubules of the kidneys. This transporter is responsible for reabsorbing sodium and chloride ions from the urine back into the bloodstream. 2. Increased Sodium and Water Excretion: By inhibiting the sodium-chloride symporter, thiazide diuretics decrease the reabsorption of sod...