Rabeprazole, Structure, Metabolism, Mechanism Of Action, Drug Interactions, Therapeutic Uses, Side Effects and Contraindications
Rabeprazole is a medication that belongs to a class of drugs known as proton pump inhibitors (PPIs). It is commonly used to treat conditions related to excess stomach acid production. Rabeprazole is available under various brand names in different countries. Some of the common brand names of rabeprazole include: 1. Aciphex 2. Pariet 3. Rabecid 4. Rabicip 5. Rablet 6. Razo 7. Razo-D 8. Rabemac 9. Rabium Please note that these brand names might vary depending on the region and country. Metabolism Rabeprazole undergoes hepatic (liver) metabolism primarily through the cytochrome P450 enzyme system, specifically the CYP2C19 enzyme. This metabolic process involves the conversion of rabeprazole into its active metabolite. The active metabolite is responsible for inhibiting the proton pump in the stomach lining, which reduces acid production. CYP2C19 is one of the key enzymes involved in the metabolism of rabeprazole. Genetic variations in the CYP2C19 gene can influence how individual...