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Showing posts with the label Proton Pump Inhibitors

Pantoprazole, Structure, Metabolism, Mechanism Of Action, Drug Interactions, Therapeutic Uses, Side Effects and Contraindications

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Pantoprazole Pantoprazole is a medication that belongs to a class of drugs known as proton pump inhibitors (PPIs). It is primarily used to treat conditions related to excessive stomach acid production. Pantoprazole is available under various brand names depending on the manufacturer and country. Some common brand names for pantoprazole include: 1. Protonix 2. Pantoloc 3. Pantozol 4. Somac 5. Panto IV 6. Pantocid 7. Zurcal 8. Controloc 9. Pantakind 10. Nolpaza Please note that availability may vary by region, and there might be additional brand names not listed here. Metabolism Pantoprazole is metabolized in the liver through a process involving the cytochrome P450 enzyme system. The primary enzyme responsible for metabolizing pantoprazole is CYP2C19, although other enzymes such as CYP3A4 and CYP2D6 may also play a role to a lesser extent. Pantoprazole undergoes hepatic metabolism to form several metabolites, including its main metabolite, desmethylpantoprazole, which is further meta...

Rabeprazole, Structure, Metabolism, Mechanism Of Action, Drug Interactions, Therapeutic Uses, Side Effects and Contraindications

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  Rabeprazole is a medication that belongs to a class of drugs known as proton pump inhibitors (PPIs). It is commonly used to treat conditions related to excess stomach acid production. Rabeprazole is available under various brand names in different countries. Some of the common brand names of rabeprazole include: 1. Aciphex 2. Pariet 3. Rabecid 4. Rabicip 5. Rablet 6. Razo 7. Razo-D 8. Rabemac 9. Rabium Please note that these brand names might vary depending on the region and country. Metabolism Rabeprazole undergoes hepatic (liver) metabolism primarily through the cytochrome P450 enzyme system, specifically the CYP2C19 enzyme. This metabolic process involves the conversion of rabeprazole into its active metabolite. The active metabolite is responsible for inhibiting the proton pump in the stomach lining, which reduces acid production. CYP2C19 is one of the key enzymes involved in the metabolism of rabeprazole. Genetic variations in the CYP2C19 gene can influence how individual...